MTHFR stands for Methylenetetrahydrofolate reductase. As the name indicates, it is a process involved with the metabolism of folate (Vitamin B9). Many know folate (or folic acid) as an important vitamin that pregnant women should take.
MTHFR is doing the conversion of Folic acid to it's active form. There are certain genes that regulate how good this process works. The two big ones are MTHFR C677T and MTHFR A1298C. If you happen to have a mutation on one or two of those, you likely have an increased risk of certain diseases due to your reduced capacity of converting folic acid into it's active form.
There are tons of co-factors involved too, so a basic protocol, if you have a mutation in these genes, would include taking the active form of folic acid, the active form of B12, and often B1, B2 and some other supplements.
Dr. Ben Lynch from Seeking Health: www.mthfr.net
...to be continued....
1.3 or 1.1 mg/day
The doctor had told the child’s mother about this and accused her of giving the child too many vitamins. She was very perplexed because she denied that she had been giving any vitamins, but they would not believe her. Because of this history, I performed the same tests and both these vitamins were indeed elevated in the blood. Because of the sugar association and the finding of vitamin B1 deficiency, I treated the child with megadoses of thiamine (vitamin B1) and sent him home. To my great surprise, not only did his health improve drastically, his feverish episodes ceased and the repeat of the blood tests showed that the levels of folate and vitamin B12 had fallen into the normal range.
I asked the mother to stop the vitamin B1 which she did reluctantly. Three or four weeks later the child had another episode of swollen glands in the neck with fever. The mother also reported that he had sleep walked and, going downstairs, he had urinated spontaneously. Of course, this implicated a mechanism in the brain. I readmitted him to the hospital and I found that the folate and B12 levels had again shot up. I treated him with thiamine again. The fever and swollen glands remitted and the levels of folate and B 12 dropped again into the normal range. Well, of course, this was a natural experiment that sent me to the library to try to come up with an explanation of the relationship between these three B vitamins. It appears to be an important phenomenon because recently, a paper has been produced in which folate and B 12 have both been found to be increased over the normal range in autism.
The Engines in the Body
First of all, I had to try to explain why there was a very obvious response to the megadose thiamine. One thing that I had learned is that the part of the brain that deals with a defense against stress becomes very irritable when cellular metabolism becomes inefficient. Thiamine deficiency in that part of the brain produces the same action as a mild to moderate lack of oxygen, because both spell “danger”. When a bacterial or viral infection attacks us, we go into a defensive mode. This is, of course, the illness. The fever makes the action of the microorganism less efficient. Swollen glands are created to catch the dead microorganisms as they are washed into the lymphatic system. My hypothetical explanation is that the thiamine deficiency created brain irritability that repeatedly went into a defensive mode under the false impression that the child was being attacked by a microorganism."
"Thiamine deficiency can express itself in many different ways, depending on which part of the brain is affected. If it can express itself in repeated episodes that exactly imitate a throat infection in one individual and autism in another, we surely have to change how we see health and disease. Both thiamine and vitamin D deficiency have been described in the medical literature as a cause of autism. I have concluded that anything that interferes with an efficient use of oxygen in the brain creates symptoms that may well be interpreted as “psychological”. Most gene mutations don’t have an effect on their own. Serious prolonged stress and/or vitamin deficient malnutrition may have to be present for the disease to be expressed."
RDA: 1.2 or 1.1 mg daily
Recommended dose when deficient:
Recent Boron video about Jorge Fletchas MD 2013 report on Boron. Because boron increases the health of the hormone system, other references report a drop in cancer rates for breast and prostate cancers in high boron areas. If you get dense or painful breasts, a number of people have treated this with high doses of iodine, so its not specifically a boron problem. Lots of people are low on iodine! Fletchas does talk of doses as high as 60 mg to 90 mg of boron per day.
In Minerals for the Genetic Code,
boron comes off as one of four magnificent
minerals — the other three being iodine,
selenium and magnesium — that belong
in the survival kit of most people in most
parts of the country. "It is probably safe
to say that most physicians no longer
remember — if they ever knew — that
boron plays a part in the body’s sugar
It was used after Chernobyl;
"OLREE; The backup system to force-fed potassium Iodine in
severe, acute radioactive poisoning is a
mineral called boron. In the entire table of
elements, including subatomic particles,
there is only one mineral that is capable of
accepting and ionizing radiation that
never changes the innards or the nucleus
of the cell — boron. The protons and the
neutrons do not change under any conditions
in the boron molecule. Boron can
take radiation and release it without upsetting
this very delicate balance."
Foods high in Boron:
highly depending on how rich the soil is in Boron
Boron antagonist: aluminium, other heavy metals
RDA: not established
It's also a natural food preservatives in foods/diminishes bacteria growth.